/* ============================================================
   DermCalc — neutral / clinical theme
   Design reference: dermcalc_wireframe.html
   ============================================================ */
/* Palette: Icy Blue #A4D8FF + Gunmetal #35393C.
   On light backgrounds the icy blue is deepened for legible accents (WCAG AA);
   the literal #A4D8FF is used for soft tints and as the dark-mode accent. */
:root{
  --bg:#f3f6fa; --panel:#ffffff; --panel-2:#f8fafd; --ink:#35393c; --muted:#646b71;
  --line:#d8e2ec; --accent:#2f7fc7; --accent-2:#1f5f9e; --accent-soft:#e3f0ff; --on-accent:#ffffff;
  --flag:#b23a48; --flag-soft:#fbeaec; --flag-line:#eecace;
  --ok:#3a7d44; --warn:#b5832b; --warn-soft:#fbf2e0;
  --radius:10px; --shadow:0 1px 3px rgba(53,57,60,.08);
  --shadow-lg:0 8px 30px rgba(53,57,60,.16);
  --mono:ui-monospace,Menlo,Consolas,"SF Mono",monospace;
  --sans:-apple-system,BlinkMacSystemFont,"Segoe UI",Roboto,Helvetica,Arial,sans-serif;
}
html[data-theme="dark"]{
  --bg:#26292c; --panel:#35393c; --panel-2:#3d4246; --ink:#eef4fb; --muted:#a7b2bd;
  --line:#474d52; --accent:#a4d8ff; --accent-2:#c4e6ff; --accent-soft:#2d3c4a; --on-accent:#1c2127;
  --flag:#e0707f; --flag-soft:#3a2126; --flag-line:#5a2f37;
  --ok:#5fae6a; --warn:#d8a857; --warn-soft:#332a16;
  --shadow:0 1px 3px rgba(0,0,0,.4); --shadow-lg:0 8px 30px rgba(0,0,0,.5);
}
*{box-sizing:border-box}
html{scroll-behavior:smooth}
body{margin:0;font-family:var(--sans);background:var(--bg);color:var(--ink);
  line-height:1.5;font-size:15px;-webkit-font-smoothing:antialiased}
a{color:var(--accent);text-decoration:none}
a:hover{text-decoration:underline}
button{font-family:inherit}

/* ---------- header ---------- */
header.app{background:var(--panel);border-bottom:1px solid var(--line);position:sticky;top:0;z-index:50}
.bar{display:flex;align-items:center;gap:14px;padding:12px 20px;max-width:1180px;margin:0 auto}
.logo{display:flex;align-items:center;gap:9px;font-weight:700;font-size:18px;letter-spacing:-.2px;
  cursor:pointer;background:none;border:none;color:var(--ink);padding:0}
.logo .mark{width:28px;height:28px;border-radius:7px;background:none;color:var(--accent);
  display:grid;place-items:center;flex-shrink:0}
.logo .mark svg{width:26px;height:26px}
.logo small{font-weight:500;color:var(--muted);font-size:12px;margin-left:2px}
.search{flex:1;max-width:440px;margin:0 auto;position:relative}
.search input{width:100%;padding:9px 14px 9px 34px;border:1px solid var(--line);border-radius:20px;
  background:var(--bg);font-size:14px;color:var(--ink)}
.search input:focus{outline:2px solid var(--accent-soft);border-color:var(--accent)}
.search .ic{position:absolute;left:12px;top:50%;transform:translateY(-50%);color:var(--muted);pointer-events:none}
.toprt{display:flex;align-items:center;gap:8px;color:var(--muted);font-size:13px}
.theme-btn{background:var(--bg);border:1px solid var(--line);border-radius:20px;width:40px;height:30px;
  display:grid;place-items:center;cursor:pointer;color:var(--muted)}
.theme-btn:hover{color:var(--accent);border-color:var(--accent)}

.chips{display:flex;gap:8px;flex-wrap:wrap;padding:10px 20px;max-width:1180px;margin:0 auto;
  border-top:1px solid transparent}
.chip{padding:6px 13px;border:1px solid var(--line);border-radius:18px;background:var(--panel);
  font-size:13px;color:var(--muted);white-space:nowrap;cursor:pointer;transition:.12s}
.chip:hover{border-color:var(--accent);color:var(--accent)}
.chip.active{background:var(--accent);color:var(--on-accent);border-color:var(--accent)}
@media(max-width:760px){.chips{flex-wrap:nowrap;overflow-x:auto;-webkit-overflow-scrolling:touch}
  .chips::-webkit-scrollbar{display:none}}

/* ---------- favourites bar ---------- */
.favbar{display:flex;gap:8px;align-items:center;flex-wrap:wrap;
  padding:8px 20px 10px;max-width:1180px;margin:0 auto;border-top:1px solid var(--line)}
.favbar[hidden]{display:none}
.favitem{display:inline-flex;align-items:stretch;border:1px solid var(--line);
  border-radius:16px;background:var(--accent-soft);overflow:hidden;transition:.12s}
.favitem:hover{border-color:var(--accent)}
.favopen{display:inline-flex;align-items:center;gap:6px;padding:5px 4px 5px 11px;
  background:none;border:none;cursor:pointer;color:var(--ink);font-size:12.5px;
  font-family:inherit;font-weight:600;white-space:nowrap}
.favopen .favstar-ic{width:13px;height:13px;flex:0 0 auto;fill:var(--accent)}
.favrm{background:none;border:none;cursor:pointer;color:var(--muted);font-size:16px;line-height:1;
  padding:0 9px 0 5px;display:grid;place-items:center}
.favrm:hover{color:var(--accent)}
@media(max-width:760px){.favbar{flex-wrap:nowrap;overflow-x:auto;-webkit-overflow-scrolling:touch}
  .favbar::-webkit-scrollbar{display:none}.favitem{flex:0 0 auto}}

/* ---------- card favourite star ---------- */
.card{position:relative}
.card h3{padding-right:24px}
.favstar{position:absolute;top:9px;right:9px;width:26px;height:26px;display:grid;
  place-items:center;border-radius:7px;cursor:pointer;color:var(--muted);
  background:none;transition:.12s;z-index:2}
.favstar svg{width:17px;height:17px;fill:none;stroke:currentColor;stroke-width:1.6}
.favstar:hover{color:var(--accent);background:var(--accent-soft)}
.favstar.on{color:var(--accent)}
.favstar.on svg{fill:var(--accent);stroke:var(--accent)}
.favstar:focus-visible{outline:2px solid var(--accent);outline-offset:1px}

main{max-width:1180px;margin:0 auto;padding:18px 20px 70px;min-height:60vh}
.secttl{font-size:13px;text-transform:uppercase;letter-spacing:.6px;color:var(--muted);
  margin:24px 0 10px;font-weight:700}
.secttl:first-child{margin-top:6px}

/* ---------- card grid ---------- */
.grid{display:grid;grid-template-columns:repeat(4,1fr);gap:14px}
.card{background:var(--panel);border:1px solid var(--line);border-radius:var(--radius);
  padding:14px;box-shadow:var(--shadow);min-height:100px;display:flex;flex-direction:column;gap:6px;
  cursor:pointer;transition:.14s;text-align:left;color:var(--ink);font-family:inherit}
.card:hover{border-color:var(--accent);transform:translateY(-2px);box-shadow:var(--shadow-lg)}
.card h3{margin:0;font-size:15px;display:flex;align-items:center;gap:6px}
.card p{margin:0;font-size:12.5px;color:var(--muted)}
.card .tag{margin-top:auto;font-size:11px;color:var(--accent);font-weight:600}
.card .lockpill{font-size:10px;color:var(--muted);font-weight:600;border:1px solid var(--line);
  border-radius:10px;padding:1px 7px}
.empty{color:var(--muted);font-size:14px;padding:40px 0;text-align:center}
@media(max-width:900px){.grid{grid-template-columns:repeat(2,1fr)}}
@media(max-width:430px){.grid{grid-template-columns:1fr 1fr;gap:10px}.card{min-height:82px;padding:11px}
  .card h3{font-size:14px}.card p{font-size:11px}}

/* ---------- tool panel ---------- */
.tool-head{display:flex;align-items:center;gap:12px;margin:4px 0 16px}
.back-btn{background:var(--panel);border:1px solid var(--line);border-radius:8px;padding:7px 12px;
  cursor:pointer;color:var(--ink);font-size:13px;font-weight:600;display:inline-flex;align-items:center;gap:6px}
.back-btn:hover{border-color:var(--accent);color:var(--accent)}
.tool-head h1{margin:0;font-size:22px;letter-spacing:-.3px}
.tool-head .sub{font-size:13px;color:var(--muted);margin-top:2px}

.panelwrap{display:grid;grid-template-columns:1fr 1fr;gap:20px;align-items:start}
.pane{background:var(--panel);border:1px solid var(--line);border-radius:var(--radius);
  padding:18px;box-shadow:var(--shadow)}
.pane.sticky{position:sticky;top:84px}
.pane h2{margin:0 0 12px;font-size:16px}
.ack{background:var(--accent-soft);border:1px solid #cfe0e4;border-radius:8px;padding:10px 12px;
  font-size:11.5px;color:var(--muted);margin-bottom:14px;line-height:1.45}
html[data-theme="dark"] .ack{border-color:var(--line)}
.note-line{font-size:12px;color:var(--muted);margin:0 0 14px}

.field{margin-bottom:14px}
.field>label,.field .qlabel{display:block;font-size:13px;color:var(--ink);margin-bottom:6px;font-weight:500}
.field .hint{font-size:11.5px;color:var(--muted);font-weight:400;margin-top:2px}
.seg-row{display:flex;gap:6px;flex-wrap:wrap}
.seg{flex:1;min-width:38px;text-align:center;border:1px solid var(--line);border-radius:7px;
  padding:9px 4px;font-size:13px;background:var(--bg);cursor:pointer;color:var(--ink);
  transition:.1s;user-select:none}
.seg:hover{border-color:var(--accent)}
.seg.sel{background:var(--accent);color:var(--on-accent);border-color:var(--accent);font-weight:600}
.seg small{display:block;font-size:9.5px;opacity:.8;font-weight:400;margin-top:1px}

input[type=number],input[type=text],select{width:100%;padding:9px 12px;border:1px solid var(--line);
  border-radius:8px;background:var(--bg);font-size:14px;color:var(--ink);font-family:inherit}
input[type=number]:focus,input[type=text]:focus,select:focus{outline:2px solid var(--accent-soft);border-color:var(--accent)}
.inline-row{display:flex;gap:10px;align-items:flex-end}
.inline-row .field{flex:1;margin-bottom:0}
.unit-toggle{display:flex;gap:0;border:1px solid var(--line);border-radius:8px;overflow:hidden;width:max-content}
.unit-toggle button{background:var(--bg);border:none;padding:8px 14px;font-size:13px;cursor:pointer;color:var(--muted)}
.unit-toggle button.on{background:var(--accent);color:var(--on-accent)}

input[type=range]{width:100%;accent-color:var(--accent)}
.range-val{font-weight:700;color:var(--accent);font-size:15px;min-width:30px;display:inline-block;text-align:right}

.check{display:flex;align-items:flex-start;gap:9px;padding:9px 11px;border:1px solid var(--line);
  border-radius:8px;background:var(--bg);margin-bottom:8px;cursor:pointer;font-size:13.5px}
.check:hover{border-color:var(--accent)}
.check input{width:18px;height:18px;margin-top:1px;accent-color:var(--accent);flex-shrink:0}
.check.on{border-color:var(--accent);background:var(--accent-soft)}

/* region blocks (PASI/EASI/SCORAD/VASI/MASI/NAPSI) */
.region{border:1px solid var(--line);border-radius:9px;padding:12px;margin-bottom:12px;background:var(--panel-2)}
.region h4{margin:0 0 10px;font-size:13.5px;color:var(--accent);display:flex;justify-content:space-between;align-items:center}
.region h4 .rsub{font-size:11px;color:var(--muted);font-weight:500}

/* ---------- result + export ---------- */
.result{background:var(--accent-soft);border:1px solid #cfe0e4;border-radius:9px;padding:16px}
html[data-theme="dark"] .result{border-color:var(--line)}
.score{font-size:38px;font-weight:800;color:var(--accent);line-height:1}
.score .max{font-size:16px;color:var(--muted);font-weight:600}
.band{display:inline-block;margin-top:8px;font-size:12px;font-weight:700;color:#fff;
  background:var(--ok);padding:3px 11px;border-radius:12px}
.band.warn{background:var(--warn)} .band.sev{background:var(--flag)} .band.neutral{background:var(--muted)}
.subscore{display:flex;gap:18px;margin-top:10px;flex-wrap:wrap}
.subscore div{font-size:13px} .subscore b{font-size:20px;color:var(--accent);display:block}
.flag{background:var(--flag-soft);border:1px solid var(--flag-line);color:var(--flag);font-size:12.5px;
  padding:10px 12px;border-radius:8px;margin-top:12px;line-height:1.45;font-weight:500}
.flag.amber{background:var(--warn-soft);border-color:#e3cf9b;color:var(--warn)}
.flag .ftitle{font-weight:700;display:block;margin-bottom:2px}

.export{margin-top:14px;background:#0f1a1f;color:#cfe6ea;font-family:var(--mono);
  font-size:11.5px;border-radius:9px;padding:14px;white-space:pre-wrap;word-break:break-word;
  max-height:340px;overflow:auto;border:1px solid #14242b}
.btnrow{display:flex;gap:8px;margin-top:12px;flex-wrap:wrap}
.btn{background:var(--accent);color:var(--on-accent);border:none;padding:9px 16px;border-radius:8px;
  font-size:13px;font-weight:600;cursor:pointer;display:inline-flex;align-items:center;gap:6px}
.btn:hover{background:var(--accent-2)}
.btn.ghost{background:var(--bg);color:var(--ink);border:1px solid var(--line)}
.btn.ghost:hover{border-color:var(--accent);color:var(--accent)}
.btn.copied{background:var(--ok)}

.toolnote{font-size:11.5px;color:var(--muted);margin-top:14px;line-height:1.5;border-top:1px solid var(--line);padding-top:12px}
.toolnote a{font-weight:600}

@media(max-width:860px){.panelwrap{grid-template-columns:1fr}.pane.sticky{position:static}
  .seg{padding:11px 4px;font-size:14px}}

/* ---------- drug DB ---------- */
.gate{background:var(--panel);border:1px solid var(--line);border-radius:var(--radius);
  padding:30px;text-align:center;box-shadow:var(--shadow);max-width:440px;margin:30px auto}
.gate .lockicon{width:48px;height:48px;margin:0 auto;color:var(--accent)}
.gate h2{margin:14px 0 4px;font-size:18px}
.gate p{font-size:12.5px;color:var(--muted);margin:0 0 4px;line-height:1.5}
.gate .gate-err{color:var(--flag);font-size:12.5px;margin-top:8px;min-height:16px}
.druglayout{display:grid;grid-template-columns:300px 1fr;gap:18px;align-items:start}
.druglist{background:var(--panel);border:1px solid var(--line);border-radius:var(--radius);
  box-shadow:var(--shadow);max-height:74vh;overflow:auto}
.drugitem{padding:11px 14px;border-bottom:1px solid var(--line);cursor:pointer}
.drugitem:hover{background:var(--accent-soft)}
.drugitem.sel{background:var(--accent-soft);border-left:3px solid var(--accent)}
.drugitem h4{margin:0;font-size:14px}
.drugitem span{font-size:11.5px;color:var(--muted)}
.drugdetail{background:var(--panel);border:1px solid var(--line);border-radius:var(--radius);
  padding:20px;box-shadow:var(--shadow)}
.drugdetail h2{margin:0 0 2px;font-size:20px}
.drugdetail .dclass{font-size:12.5px;color:var(--accent);font-weight:600;margin-bottom:14px}
.dsection{margin-bottom:14px}
.dsection h5{margin:0 0 5px;font-size:11.5px;text-transform:uppercase;letter-spacing:.5px;color:var(--accent)}
.dsection ul{margin:0;padding-left:18px;font-size:13.5px}
.dsection ul li{margin-bottom:3px}
.dsection p{margin:0;font-size:13.5px}
@media(max-width:860px){.druglayout{grid-template-columns:1fr}.druglist{max-height:auto;max-height:300px}}

/* Local pathways & protocols links (per-drug + general panel) */
.dpathways{list-style:none;margin:0;padding:0;display:flex;flex-direction:column;gap:4px}
.dpathways li{margin:0}
.dpathways a{display:inline-flex;align-items:center;gap:6px;font-size:13px;color:var(--accent);
  text-decoration:none;padding:5px 9px;border-radius:7px;background:var(--accent-soft);border:1px solid transparent}
.dpathways a:hover{border-color:var(--accent);text-decoration:underline}
.dpathways a::before{content:'\1F4CE';font-size:11px}
.dsection-pathways h5{color:var(--warn,var(--accent))}
.general-pathways{margin-bottom:16px;border:1px solid var(--line);border-radius:var(--radius);
  background:var(--panel);padding:0;box-shadow:var(--shadow)}
.general-pathways summary{cursor:pointer;padding:12px 16px;font-size:13px;font-weight:600;
  list-style:none;color:var(--accent)}
.general-pathways summary::-webkit-details-marker{display:none}
.general-pathways summary::before{content:'▸ ';display:inline-block;transition:transform .15s}
.general-pathways[open] summary::before{transform:rotate(90deg)}
.gp-body{padding:0 16px 14px;display:grid;grid-template-columns:repeat(auto-fit,minmax(220px,1fr));gap:14px}
.gp-group h6{margin:0 0 6px;font-size:11px;text-transform:uppercase;letter-spacing:.4px;color:var(--muted)}

/* ---------- resources ---------- */
.res-group{margin-bottom:26px}
.res-group>h3{font-size:15px;margin:0 0 10px}
.restable{width:100%;border-collapse:collapse;background:var(--panel);border:1px solid var(--line);
  border-radius:var(--radius);overflow:hidden;font-size:13px;box-shadow:var(--shadow)}
.restable th{background:var(--accent-soft);text-align:left;padding:10px 12px;font-size:11px;
  text-transform:uppercase;letter-spacing:.4px;color:var(--accent);font-weight:700}
html[data-theme="dark"] .restable th{color:var(--accent-2)}
.restable td{padding:10px 12px;border-top:1px solid var(--line);vertical-align:top}
.restable tr:hover td{background:var(--panel-2)}
.qrcard-grid{display:grid;grid-template-columns:repeat(4,1fr);gap:14px}
.qrcard{background:var(--panel);border:1px solid var(--line);border-radius:var(--radius);padding:14px;
  text-align:center;box-shadow:var(--shadow)}
.qrcard .qrbox{width:120px;height:120px;margin:0 auto 10px;background:#fff;border-radius:6px;padding:6px}
.qrcard .qrbox canvas,.qrcard .qrbox img{width:100%;height:100%}
.qrcard h5{margin:0 0 3px;font-size:13px}
.qrcard p{margin:0 0 6px;font-size:11px;color:var(--muted)}
@media(max-width:900px){.qrcard-grid{grid-template-columns:repeat(2,1fr)}}
@media(max-width:480px){.qrcard-grid{grid-template-columns:1fr 1fr}.restable{font-size:12px}
  .restable th,.restable td{padding:8px 8px}}

.bio-table-wrap{overflow-x:auto}
.bio-table{width:100%;border-collapse:collapse;font-size:12px;min-width:760px;background:var(--panel)}
.bio-table th{background:var(--accent-soft);color:var(--accent);text-align:left;padding:9px 10px;
  font-size:10.5px;text-transform:uppercase;letter-spacing:.3px;vertical-align:top}
html[data-theme="dark"] .bio-table th{color:var(--accent-2)}
.bio-table td{padding:9px 10px;border-top:1px solid var(--line);vertical-align:top;line-height:1.45}
.bio-table td strong{color:var(--accent)}
.callout{background:var(--warn-soft);border:1px solid #e3cf9b;border-radius:9px;padding:14px 16px;
  font-size:13px;margin:16px 0;line-height:1.55}
html[data-theme="dark"] .callout{border-color:#5a4a23}
.callout h4{margin:0 0 6px;font-size:13.5px;color:var(--warn)}

/* ---------- footer ---------- */
footer.disc{background:var(--panel-2);border-top:1px solid var(--line);color:var(--muted);
  font-size:11.5px;text-align:center;padding:16px 20px;line-height:1.6}
footer.disc a{font-weight:600}

.hide{display:none!important}

/* ---------- grading guide (severity image keys) ---------- */
details.gg{margin:6px 0 14px;border:1px solid var(--line);border-radius:var(--radius);
  background:var(--panel-2);overflow:hidden}
details.gg>summary.gg-sum{cursor:pointer;list-style:none;padding:8px 12px;font-size:12.5px;
  font-weight:600;color:var(--accent-2);display:flex;align-items:center;gap:6px;user-select:none}
details.gg>summary.gg-sum::-webkit-details-marker{display:none}
details.gg .gg-ico{transition:transform .18s ease;display:inline-block;font-size:11px}
details.gg[open] .gg-ico{transform:rotate(90deg)}
.gg-grid{display:grid;grid-template-columns:repeat(auto-fit,minmax(96px,1fr));gap:8px;
  padding:4px 12px 12px}
.gg-cell{border:1px solid var(--line);border-radius:8px;background:var(--panel);
  padding:6px;text-align:center;display:flex;flex-direction:column}
.gg-swatch{position:relative;width:100%;height:56px;border-radius:6px;overflow:hidden;
  border:1px solid rgba(0,0,0,.08);margin-bottom:5px}
.gg-grade{font-size:11.5px;font-weight:700;color:var(--ink);line-height:1.2}
.gg-desc{font-size:10.5px;color:var(--muted);line-height:1.3;margin-top:3px}
.gg-soc{margin:0 12px 8px;font-size:11px;line-height:1.45;color:var(--ink);
  background:var(--warn-soft);border:1px solid var(--warn);border-radius:8px;padding:7px 9px}
.gg-note{margin:0 12px 8px;font-size:10.5px;color:var(--muted);line-height:1.4;font-style:italic}
.gg-cite{margin:0 12px 12px;font-size:10px;color:var(--muted);line-height:1.45}
.gg-cite .gg-fv{display:inline-block;font-weight:700;color:var(--warn);
  border:1px solid var(--warn);border-radius:4px;padding:0 4px;margin-right:4px;font-size:9px;
  text-transform:uppercase;letter-spacing:.03em}
.gg-block{margin:0 0 16px;padding:10px 12px;border:1px dashed var(--line);
  border-radius:var(--radius);background:var(--accent-soft)}
.gg-block-h{font-size:12px;font-weight:700;color:var(--accent-2);
  text-transform:uppercase;letter-spacing:.04em;margin-bottom:8px}
.gg-block details.gg{margin:6px 0;background:var(--panel)}

/* ============================================================
   Contact allergen reference (allergens.js)
   ============================================================ */
.al-controls{display:flex;flex-wrap:wrap;gap:10px;align-items:center;margin:14px 0 10px}
.al-search{flex:1 1 280px;min-width:0;padding:9px 12px;font-size:14px;font-family:var(--sans);
  color:var(--ink);background:var(--panel);border:1px solid var(--line);border-radius:8px}
.al-search:focus{outline:none;border-color:var(--accent);box-shadow:0 0 0 2px var(--accent-soft)}
.al-fchips{display:flex;flex-wrap:wrap;gap:6px}
.al-fchip{cursor:pointer;font-family:var(--sans);font-size:12px;font-weight:600;
  padding:6px 11px;border-radius:999px;border:1px solid var(--line);
  background:var(--panel);color:var(--muted);transition:all .15s ease}
.al-fchip:hover{border-color:var(--accent);color:var(--accent)}
.al-fchip.on{background:var(--accent);border-color:var(--accent);color:var(--on-accent)}
.al-count{margin:0 0 12px}
.al-list{display:flex;flex-direction:column;gap:8px}
details.al-item{border:1px solid var(--line);border-radius:var(--radius);
  background:var(--panel);overflow:hidden}
details.al-item>summary.al-sum{cursor:pointer;list-style:none;display:flex;
  align-items:center;gap:10px;flex-wrap:wrap;padding:11px 14px;font-family:var(--sans)}
details.al-item>summary.al-sum::-webkit-details-marker{display:none}
details.al-item[open]{border-color:var(--accent)}
.al-ico{transition:transform .18s ease;display:inline-block;font-size:11px;color:var(--muted)}
details.al-item[open] .al-ico{transform:rotate(90deg)}
.al-name{font-size:14px;font-weight:700;color:var(--ink)}
.al-cat{font-size:11px;color:var(--muted);padding:2px 7px;border:1px solid var(--line);
  border-radius:999px;background:var(--panel-2)}
.al-badges{display:flex;flex-wrap:wrap;gap:4px;margin-left:auto}
.al-badge{font-size:10px;font-weight:700;letter-spacing:.02em;padding:2px 7px;
  border-radius:999px;border:1px solid transparent;white-space:nowrap}
.al-b-british{background:#e6eef0;color:#1f4e5a;border-color:#cfe0e4}
.al-b-european{background:#e8eef6;color:#2b4a73;border-color:#d3def0}
.al-b-facial{background:#f3ebf5;color:#6b3d75;border-color:#e6d7ea}
.al-b-fragrance{background:#fbf2e0;color:#8a5e16;border-color:#f0e0bf}
.al-b-preservative{background:#e6f1ea;color:#2f6b44;border-color:#cfe5d6}
html[data-theme="dark"] .al-b-british{background:#1d2c33;color:#8fc4d2;border-color:#2a4049}
html[data-theme="dark"] .al-b-european{background:#1b2734;color:#9bbce0;border-color:#2a3a4c}
html[data-theme="dark"] .al-b-facial{background:#2a1f2e;color:#cba3d4;border-color:#3e2e44}
html[data-theme="dark"] .al-b-fragrance{background:#332a16;color:#d8b86a;border-color:#4a3d20}
html[data-theme="dark"] .al-b-preservative{background:#19281f;color:#86c79b;border-color:#2a3f30}
.al-detail{padding:4px 14px 14px;border-top:1px solid var(--line);background:var(--panel-2)}
.al-row{display:grid;grid-template-columns:120px 1fr;gap:10px;padding:8px 0;
  border-bottom:1px solid var(--line);font-size:13px;line-height:1.5}
.al-row:last-child{border-bottom:none}
.al-k{font-size:11px;font-weight:700;text-transform:uppercase;letter-spacing:.04em;
  color:var(--muted);padding-top:1px}
.al-v{color:var(--ink)}
.al-leafrow{display:flex;flex-wrap:wrap;gap:8px}
.al-leaf{font-weight:600;font-size:12.5px;padding:5px 10px;border:1px solid var(--line);
  border-radius:7px;background:var(--panel);color:var(--accent);text-decoration:none;
  transition:all .15s ease}
.al-leaf:hover{border-color:var(--accent);background:var(--accent-soft)}
@media(max-width:520px){
  .al-row{grid-template-columns:1fr;gap:2px}
  .al-badges{margin-left:0;width:100%}
}
.al-srcrow{display:flex;flex-wrap:wrap;gap:6px}
.al-src{font-size:11.5px;color:var(--muted);text-decoration:none;padding:3px 8px;
  border:1px solid var(--line);border-radius:6px;background:var(--panel);transition:all .15s ease}
.al-src:hover{border-color:var(--accent);color:var(--accent)}
.al-fv{display:inline-block;font-size:9px;font-weight:700;color:var(--warn);
  text-transform:uppercase;letter-spacing:.05em;margin-left:5px;
  border:1px solid var(--warn);border-radius:4px;padding:0 4px;vertical-align:middle}

/* ============================================================
   Therapeutics database (therapeutics.js)
   ============================================================ */
.th-srcline{display:block;margin-top:6px;font-size:11px;color:var(--muted);font-style:italic}
.th-key{display:flex;flex-wrap:wrap;align-items:center;gap:10px;margin:0 0 12px;
  padding:10px 12px;border:1px dashed var(--line);border-radius:var(--radius);background:var(--panel-2)}
.th-keyh{font-size:11px;font-weight:700;text-transform:uppercase;letter-spacing:.04em;color:var(--accent-2)}
.th-keyitem{display:inline-flex;align-items:center;gap:5px}
.th-keylbl{font-size:11px;color:var(--muted)}
.th-grade{display:inline-flex;align-items:center;justify-content:center;min-width:20px;height:20px;
  padding:0 5px;border-radius:5px;font-size:11px;font-weight:800;line-height:1;border:1px solid transparent}
.th-g-A{background:#1f6b3a;color:#fff}
.th-g-B{background:#3a7d6b;color:#fff}
.th-g-C{background:#b5832b;color:#fff}
.th-g-D{background:#bd6a36;color:#fff}
.th-g-E{background:#9a5560;color:#fff}
.th-g-none{background:var(--panel-2);color:var(--muted);border-color:var(--line)}
.th-meta{margin-left:auto;font-size:11px;color:var(--muted);white-space:nowrap}
.th-detail{padding:8px 14px 14px}
.th-summary{font-size:13px;color:var(--ink);line-height:1.55;margin:6px 0 12px}
.th-block{margin:0 0 14px}
.th-block>h5{font-size:11px;font-weight:700;text-transform:uppercase;letter-spacing:.04em;
  color:var(--accent-2);margin:0 0 7px}
.th-line-first>h5{color:#1f6b3a}
.th-line-second>h5{color:#3a7d6b}
.th-line-third>h5{color:#bd6a36}
.th-inv{margin:0;padding-left:18px;font-size:13px;line-height:1.55;color:var(--ink)}
.th-inv li{margin:2px 0}
.th-tx{list-style:none;margin:0;padding:0;display:flex;flex-direction:column;gap:4px}
.th-tx li{display:flex;align-items:center;gap:10px;padding:6px 10px;border:1px solid var(--line);
  border-radius:7px;background:var(--panel);font-size:13px}
.th-txname{flex:1;color:var(--ink)}
.th-none{padding:4px 0}
details.th-refs{margin-top:6px;border:1px solid var(--line);border-radius:8px;background:var(--panel-2)}
details.th-refs>summary{cursor:pointer;list-style:none;padding:8px 12px;font-size:12px;font-weight:700;
  color:var(--accent-2);text-transform:uppercase;letter-spacing:.03em}
details.th-refs>summary::-webkit-details-marker{display:none}
details.th-refs>summary::before{content:'▸ ';color:var(--muted)}
details.th-refs[open]>summary::before{content:'▾ '}
.th-reflist{margin:0;padding:4px 16px 12px 30px;font-size:12px;line-height:1.5}
.th-reflist li{margin:0 0 9px;color:var(--ink)}
.th-cite{color:var(--ink)}
.th-pm{font-weight:600;white-space:nowrap;margin-left:4px}
.th-refnote{font-size:11.5px;color:var(--muted);font-style:italic;margin-top:2px;line-height:1.45}
.th-pageref{margin-top:10px;padding-top:8px;border-top:1px solid var(--line)}

/* ===== Library (PDF reader) ===== */
.lib-searchbar{display:flex;gap:12px;align-items:flex-end;margin-bottom:14px;flex-wrap:wrap}
.lib-mode{display:flex;gap:0;border:1px solid var(--line);border-radius:8px;overflow:hidden}
.lib-mode .seg{background:var(--panel);border:none;border-right:1px solid var(--line);padding:9px 14px;
  font-size:13px;color:var(--ink);cursor:pointer}
.lib-mode .seg:last-child{border-right:none}
.lib-mode .seg.sel{background:var(--accent);color:var(--on-accent)}
.lib-shelf{display:grid;grid-template-columns:repeat(auto-fill,minmax(280px,1fr));gap:14px}
.lib-book{display:flex;gap:12px;align-items:flex-start;text-align:left;background:var(--panel);
  border:1px solid var(--line);border-radius:var(--radius);padding:14px;cursor:pointer;transition:border-color .15s}
.lib-book:hover{border-color:var(--accent)}
.lib-cover{flex:0 0 44px;height:44px;display:flex;align-items:center;justify-content:center;
  background:var(--accent-soft);color:var(--accent);border-radius:8px}
.lib-bmeta{flex:1;min-width:0}
.lib-bmeta h4{margin:0 0 3px;font-size:14.5px;line-height:1.3}
.lib-bmeta>span{font-size:11.5px;color:var(--muted)}
.lib-tags{margin-top:6px;display:flex;gap:5px;flex-wrap:wrap}
.lib-tags em{font-style:normal;font-size:10.5px;color:var(--muted);border:1px solid var(--line);
  border-radius:20px;padding:1px 8px}
.lib-book .tag{align-self:center;color:var(--accent);font-size:12px;font-weight:600;white-space:nowrap}
.lib-hits{display:flex;flex-direction:column;gap:8px;margin-top:6px}
.lib-hit{text-align:left;background:var(--panel);border:1px solid var(--line);border-radius:9px;
  padding:11px 13px;cursor:pointer;transition:border-color .15s}
.lib-hit:hover{border-color:var(--accent)}
.lib-hit-top{display:flex;justify-content:space-between;gap:10px;font-size:13px;margin-bottom:4px}
.lib-hit-top span{color:var(--muted);font-size:11.5px;white-space:nowrap}
.lib-hit-snip{font-size:12.5px;color:var(--muted);line-height:1.5}
.lib-hit-snip mark,.lib-hit-snip b mark{background:var(--accent-soft);color:var(--ink);padding:0 2px;border-radius:3px}
/* reader */
.rd-toolbar{display:flex;gap:14px;align-items:center;flex-wrap:wrap;background:var(--panel);
  border:1px solid var(--line);border-radius:10px;padding:8px 10px;margin-bottom:12px;position:sticky;top:8px;z-index:5}
.rd-nav,.rd-zoom{display:flex;align-items:center;gap:6px}
.rd-toolbar .btn.ghost{padding:5px 10px;font-size:14px;line-height:1}
.rd-pageind{font-size:13px;color:var(--muted)}
.rd-pageind input{width:48px;padding:5px 6px;border:1px solid var(--line);border-radius:6px;
  background:var(--bg);color:var(--ink);font-size:13px;text-align:center}
#rdZoomLvl{font-size:12.5px;color:var(--muted);min-width:42px;text-align:center}
.rd-find{display:flex;align-items:center;gap:6px;margin-left:auto !important}
.rd-find input{width:180px;padding:6px 9px;border:1px solid var(--line);border-radius:7px;
  background:var(--bg);color:var(--ink);font-size:13px}
.rd-findcount{font-size:11.5px;color:var(--muted);min-width:70px}
.rd-stage{background:var(--panel-2);border:1px solid var(--line);border-radius:10px;
  padding:18px;overflow:auto;max-height:78vh;display:flex;justify-content:flex-start;
  align-items:flex-start;min-width:0}
/* Centre the page when it fits, but flex-start so it never gets clipped
   on the left when wider than the stage (justify-content:center +
   overflow:auto silently hides the negative-scroll region). */
.rd-canvaswrap{margin-left:auto;margin-right:auto}
/* Two-page spread — the wrap becomes a horizontal flex row whose two
   canvases sit side by side with a small visual gap (book gutter). */
.rd-canvaswrap.rd-spread{display:flex;flex-direction:row;align-items:flex-start;gap:12px}
.rd-canvaswrap canvas + canvas{margin-left:0}

/* Rotate / Spread toolbar buttons — same visual treatment as Contents. */
.rd-mini-toggle{display:flex;align-items:center;gap:5px;font-size:12.5px;
  border:1px solid var(--line) !important;border-radius:7px !important}
.rd-mini-toggle[aria-pressed="true"]{background:var(--accent-soft) !important;color:var(--accent) !important}
/* Without flex-shrink:0 + min-width:0 on the wrap, a narrow grid column
   can compress the canvas (which sets its size via style.width set in
   JS) into a sliver. We pin both axes here so the canvas is always
   rendered at the size pdf.js asked for and overflow scrolls instead. */
.rd-canvaswrap{box-shadow:0 2px 14px rgba(53,57,60,.18);
  flex:0 0 auto;max-width:none}
.rd-canvaswrap canvas{display:block;border-radius:2px;max-width:none}
/* Each rendered page is wrapped in a positioned slot so the text layer
   (and search highlights) can overlay it precisely. Two slots when in
   spread mode — they sit side by side via the parent flex row. */
.rd-pageslot{position:relative;flex:0 0 auto;line-height:0}
.rd-textlayer{position:absolute;left:0;top:0;width:100%;height:100%;
  overflow:hidden;line-height:1;pointer-events:none;
  /* span text is invisible by default — we only want the highlight boxes
     to show. Use "transparent" text colour rather than opacity:0 so the
     <mark> background colour still renders normally. */
  color:transparent;-webkit-text-fill-color:transparent}
.rd-textlayer span{position:absolute;white-space:pre;transform-origin:0% 0%}
.rd-textlayer mark.rd-hl{background:rgba(255, 215, 0, .55);color:transparent;
  border-radius:2px;padding:0 1px;box-decoration-break:clone;
  -webkit-box-decoration-break:clone}
.rd-textlayer mark.rd-hl-active{background:rgba(255, 140, 0, .75);
  outline:2px solid rgba(255,140,0,.95);outline-offset:0}

/* Per-book card badges (size + page count). */
.lib-badges{display:flex;flex-wrap:wrap;gap:5px;margin-top:6px}
.lib-badge{display:inline-block;font-style:normal;font-size:10.5px;line-height:1;
  padding:3px 7px;border:1px solid var(--line);border-radius:99px;color:var(--muted);
  background:var(--bg)}
.lib-badge-size{}
.lib-badge-pages{}

/* Fullscreen toggle button — sits next to Contents. */
.rd-fs-toggle{display:flex;align-items:center;gap:5px;font-size:12.5px;
  border:1px solid var(--line) !important;border-radius:7px !important}
.rd-fs-toggle[aria-pressed="true"]{background:var(--accent-soft) !important;color:var(--accent) !important}

/* Fullscreen mode — reader takes the whole viewport. The browser puts
   the element directly under :fullscreen so we use both the API
   pseudo-class and our own class for robustness across engines. */
.rd-host--fs,
:fullscreen .rd-host--fs,
:-webkit-full-screen .rd-host--fs{background:var(--bg)}
.rd-host--fs{padding:14px 16px;overflow:auto;height:100vh;width:100vw;
  display:flex;flex-direction:column}
.rd-host--fs .tool-head{margin-bottom:6px}
.rd-host--fs .rd-body{flex:1 1 auto;min-height:0}
.rd-host--fs .rd-stage{max-height:none;flex:1 1 auto}
/* responsive media queries moved to outline panel section below */


/* ===== Library reader — outline/chapter panel (appended) ===== */

/* Two-column layout: TOC panel + canvas stage */
.rd-body{display:grid;grid-template-columns:240px 1fr;gap:0;align-items:start;min-height:0}
.rd-body.rd-body--notoc{grid-template-columns:0 1fr}
.rd-body.rd-body--notoc .rd-toc{display:none}

/* Outline panel */
.rd-toc{background:var(--panel);border:1px solid var(--line);border-radius:10px;
  overflow:hidden;position:sticky;top:8px;max-height:78vh;display:flex;flex-direction:column;
  margin-right:12px}
.rd-toc-head{padding:10px 12px 8px;font-size:11px;font-weight:700;text-transform:uppercase;
  letter-spacing:.05em;color:var(--muted);border-bottom:1px solid var(--line);flex:0 0 auto}
.rd-toc-body{overflow-y:auto;flex:1 1 auto;overscroll-behavior:contain}
.rd-toc-body::-webkit-scrollbar{width:4px}
.rd-toc-body::-webkit-scrollbar-thumb{background:var(--line);border-radius:4px}

.rd-toc-list{list-style:none;margin:0;padding:4px 0}
.rd-toc-item{display:block}
.rd-toc-btn{display:flex;align-items:baseline;gap:0;width:100%;text-align:left;
  background:none;border:none;padding:5px 10px;cursor:pointer;font-size:12.5px;
  color:var(--ink);line-height:1.4;transition:background .1s}
.rd-toc-btn:hover{background:var(--accent-soft)}
.rd-toc-btn:disabled{cursor:default;color:var(--muted);opacity:.5}
.rd-toc-indent{display:inline-block;flex:0 0 auto}
.rd-toc-label{flex:1;min-width:0;overflow:hidden;text-overflow:ellipsis;white-space:nowrap}
.rd-toc-pg{flex:0 0 auto;font-size:11px;color:var(--muted);margin-left:6px}

/* depth variants */
.rd-toc-d0>.rd-toc-btn{font-weight:600;font-size:12.5px;padding-top:6px;padding-bottom:6px}
.rd-toc-d1>.rd-toc-btn{font-size:12px}
.rd-toc-d2>.rd-toc-btn,.rd-toc-d3>.rd-toc-btn{font-size:11.5px;color:var(--muted)}

/* active item */
.rd-toc-active>.rd-toc-btn{background:var(--accent-soft);color:var(--accent)}
.rd-toc-active>.rd-toc-btn .rd-toc-pg{color:var(--accent)}

/* empty / loading states */
.rd-toc-loading,.rd-toc-empty{padding:14px 12px;font-size:12px;color:var(--muted);line-height:1.5}
.rd-toc-empty span{display:block;font-size:11px;margin-top:4px}

/* TOC toggle button */
.rd-toc-toggle{display:flex;align-items:center;gap:5px;font-size:12.5px;
  border:1px solid var(--line) !important;border-radius:7px !important}
.rd-toc-toggle[aria-pressed="true"]{background:var(--accent-soft) !important;color:var(--accent) !important}

/* dark mode */
html[data-theme="dark"] .rd-toc{background:var(--panel)}
html[data-theme="dark"] .rd-toc-active>.rd-toc-btn{color:var(--accent)}

/* responsive: collapse TOC below 860px */
@media(max-width:860px){
  .rd-body{grid-template-columns:1fr}
  .rd-body .rd-toc{display:none}
  .rd-body.rd-body--toc-mobile .rd-toc{display:flex;position:static;margin:0 0 12px;max-height:220px}
  .rd-toc-toggle{display:none}
}
@media(max-width:680px){
  .rd-find{margin-left:0 !important;width:100%}
  .rd-find input{flex:1;width:auto}
  .rd-toolbar{position:static}
  .rd-stage{padding:8px}
}

/* ---- AD biologics vs JAK table: responsive stacked cards ---- */
@media(max-width:700px){
  .ad-table,.ad-table tbody,.ad-table tr,.ad-table td{display:block;width:100%;min-width:0}
  .ad-table thead{display:none}
  .bio-table-wrap:has(.ad-table){overflow:visible}
  .ad-table tr{border:1px solid var(--line);border-radius:9px;margin-bottom:12px;background:var(--panel)}
  .ad-table td{border:none;border-top:1px solid var(--line);padding:9px 12px;line-height:1.5}
  .ad-table td:first-child{border-top:none}
  .ad-table td::before{content:attr(data-label);display:block;font-size:10px;text-transform:uppercase;letter-spacing:.6px;color:var(--muted);margin-bottom:3px;font-weight:600}
  .ad-table td b{color:var(--accent)}
  .ad-table tr:hover td{background:none}
}